Few diagnostic tools are available for diagnostic procedures relating to prosthetic joint infection (PJI). Available diagnostic test holds either insufficient diagnostic accuracy, or are not cost-effective for the health care system.

In-house students on performance of CLP test in synovial fluid biopsies. Results correspond to measured Calprotectin levels in samples documented in the literature.

Calprotectin excludes PJI in 15 minutes

Ruling out infection is the number one priority for the orthopaedic surgeon. PJI can lead to additional surgeries, revision, possibly amputation, and increased patient discomfort.

When encountering patients with painful joints, the orthopaedic consultant must consider the possibility for infection. Rapidly ruling out infection creates the opportunity for same-day diagnostics for evidence based patient flow decisions.

Lyfstone® Calprotectin for Synovial Fluid is a novel PJI biomarker. Calprotectin (CLP) is abundantly present in neutrophils. Presence of neutrophils is a hallmark of PJI, and a massive release of CLP occurs upon encounter with pathogens.

Elevated levels of CLP have been demonstrated to hold excellent diagnostic precision for both acute and chronic PJI, with excellent negative prediction value (NPV) for ruling out infection in suspected PJI patients.