Be sure.
faster.
why lyfstone® calprotectin?
EASY TO USe
clinically proven
Using 2013 Musculoskeletal Infection Society criteria, the POC test demonstrated a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of 98.1%, 95.7%, 94.5%, 98.5%, and 0.969, respectively. Using the 2018 ICM, the POC test demonstrated a sensitivity, specificity, PPV, NPV, and AUC of 98.2%, 98.5%, 98.2%, 98.5%, and 0.984, respectively. Using the 2019 proposed European Bone and Joint Infection Society criteria, the POC test demonstrated a sensitivity, specificity, PPV, NPV, and AUC of 93.2%, 100.0%, 100.0%, 94.2%, and 0.966, respectively.
Performance characteristics of LYFCLP005 at 50mg/L
| Criteria | Sensitivity | Specificity | Negative prediction value | Positive prediction value | Area under the curve |
|---|---|---|---|---|---|
| MSIS13 | 98.1% | 95.7% | 98.5% | 94.5% | 0.969 |
| 2018 ICM | 98.2% | 98.5% | 98.5% | 98.2% | 0.984 |
| EBJIS criteria | 93.2% | 100.0% | 94.2% | 100.0% | 0.966 |
A NEW ADVANCEMENT IN DIAGNOSING PJI
Improving quality of life
Lyfstone® enables the early identification of periprosthetic joint infection, which can prevent later complications or further surgeries.
TIME SAVING
The surgeon can extract the synovial fluid and perform the test immediately while the patient is still present.
COST SAVING
Faster PJI diagnosis results in less bed-days for the patient.
Product Testimonials
We are proud to share the latest feedback from our users about Lyfstone®.
Dr Peter Young
NHS England, Ayrshire & Arran
“It is the flexibility of using calprotectin in patients with slightly blood-stained fluid, the traffic light risk assessment and the ability to collect the data that make the Calprotectin system an excellent adjunct to the Orthopaedic armamentarium in diagnosis and treatment of PJI.“
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product materials
Synovial calprotectin
is a reliable biomarker for periprosthetic joint infections in acute-phase inflammation — a prospective cohort study
Diagnosing periprosthetic joint infections (PJI) is challenging and may be hampered by the presence of other causes of local inflammation…
Calprotectin Lateral
Flow Test:
Consistent Across Criteria for Ruling Out Periprosthetic Joint Infection.
Background: There are multiple sets of criteria used to define periprosthetic joint infection. The objective of this study is to…
Diagnostic Utility
of a Novel Point-of-Care Test of Calprotectin for PJI after TKA: A Prospective Cohort Study
Diagnostic Utility
of a Novel Point-of-Care Test of Calprotectin for PJI after TKA: A Prospective Cohort Study
Background: Despite several synovial fluid biomarkers for the diagnosis of periprosthetic joint infection (PJI) having been investigated, point-of-care…
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