Be sure.
faster.

Innovation in PJI-diagnostics
Lyfstone® Calprotectin – an innovative bedside rapid test to rule-out prosthetic joint infection (PJI) from the patient’s synovial fluid in only 15 minutes. Professional solution for surgeons to provide a precise diagnosis and make the right decision faster and more efficiently.

why lyfstone® calprotectin?

EASY TO USe

To assess the risk of periprosthetic joint infection, a small amount of synovial fluid is extracted from the patient’s joint. The Lyfstone® test requires only 20 μl and generates results in 15 minutes. The easy sample work-up allows implementation at any stage of care, from consulting to pre-op to per-op.

clinically proven

Using 2013 Musculoskeletal Infection Society criteria, the POC test demonstrated a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of 98.1%, 95.7%, 94.5%, 98.5%, and 0.969, respectively. Using the 2018 ICM, the POC test demonstrated a sensitivity, specificity, PPV, NPV, and AUC of 98.2%, 98.5%, 98.2%, 98.5%, and 0.984, respectively. Using the 2019 proposed European Bone and Joint Infection Society criteria, the POC test demonstrated a sensitivity, specificity, PPV, NPV, and AUC of 93.2%, 100.0%, 100.0%, 94.2%, and 0.966, respectively.

Reference.

Performance characteristics of LYFCLP005 at 50mg/L

Criteria Sensitivity Specificity Negative prediction value Positive prediction value Area under the curve
MSIS13 98.1% 95.7% 98.5% 94.5% 0.969
2018 ICM 98.2% 98.5% 98.5% 98.2% 0.984
EBJIS criteria 93.2% 100.0% 94.2% 100.0% 0.966

A NEW ADVANCEMENT IN DIAGNOSING PJI

The Lyfstone® Calprotectin POC test is a new, advanced diagnostic aid that helps orthopaedic surgeons make better-informed decisions, faster and more accurately. It’s easy to use and identifies the risk of periprosthetic joint infection (PJI) in 15 minutes.

Improving quality of life

Lyfstone® enables the early identification of periprosthetic joint infection, which can prevent later complications or further surgeries.

TIME SAVING

The surgeon can extract the synovial fluid and perform the test immediately while the patient is still present.

COST SAVING

Faster PJI diagnosis results in less bed-days for the patient.

Product Testimonials

We are proud to share the latest feedback from our users about Lyfstone®.

Dr Peter Young

NHS England, Ayrshire & Arran

“It is the flexibility of using calprotectin in patients with slightly blood-stained fluid, the traffic light risk assessment and the ability to collect the data that make the Calprotectin system an excellent adjunct to the Orthopaedic armamentarium in diagnosis and treatment of PJI.“

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frequently asked questions

Do you have any more questions regarding Lyfstone®?

product materials

Learn more about Lyfstone® from our blog and professional product materials

Synovial calprotectin
is a reliable biomarker for periprosthetic joint infections in acute-phase inflammation — a prospective cohort study

Diagnosing periprosthetic joint infections (PJI) is challenging and may be hampered by the presence of other causes of local inflammation…

Calprotectin Lateral
Flow Test:

Consistent Across Criteria for Ruling Out Periprosthetic Joint Infection.

BackgroundThere are multiple sets of criteria used to define periprosthetic joint infection. The objective of this study is to…

Diagnostic Utility
of a Novel Point-of-Care Test of Calprotectin for PJI after TKA: A Prospective Cohort Study

Diagnostic Utility
of a Novel Point-of-Care Test of Calprotectin for PJI after TKA: A Prospective Cohort Study

BackgroundDespite several synovial fluid biomarkers for the diagnosis of periprosthetic joint infection (PJI) having been investigated, point-of-care…

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Our professional distributors
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Get in touch with

our distributors

in europe

Our professional distributors
are available throughout Europe. Choose the one closest to you and contact your sales representative today.