Be sure.
faster.

Innovation in PJI-diagnostics
Lyfstone® Calprotectin – an innovative bedside rapid test to rule-out prosthetic joint infection (PJI) from the patient’s synovial fluid in only 15 minutes. Professional solution for surgeons to provide a precise diagnosis and make the right decision faster and more efficiently.

why lyfstone® calprotectin?

EASY TO USe

To assess the risk of periprosthetic joint infection, a small amount of synovial fluid is extracted from the patient’s joint. The Lyfstone® test requires only 20 μl and generates results in 15 minutes. The easy sample work-up allows implementation at any stage of care, from consulting to pre-op to per-op.

clinically proven

Using 2013 Musculoskeletal Infection Society criteria, the POC test demonstrated a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of 98.1%, 95.7%, 94.5%, 98.5%, and 0.969, respectively. Using the 2018 ICM, the POC test demonstrated a sensitivity, specificity, PPV, NPV, and AUC of 98.2%, 98.5%, 98.2%, 98.5%, and 0.984, respectively. Using the 2019 proposed European Bone and Joint Infection Society criteria, the POC test demonstrated a sensitivity, specificity, PPV, NPV, and AUC of 93.2%, 100.0%, 100.0%, 94.2%, and 0.966, respectively.

Reference.

Performance characteristics of LYFCLP005 at 50mg/L

Criteria Sensitivity Specificity Negative prediction value Positive prediction value Area under the curve
MSIS13 98.1% 95.7% 98.5% 94.5% 0.969
2018 ICM 98.2% 98.5% 98.5% 98.2% 0.984
EBJIS criteria 93.2% 100.0% 94.2% 100.0% 0.966

A NEW ADVANCEMENT IN DIAGNOSING PJI

The Lyfstone® Calprotectin POC test is a new, advanced diagnostic aid that helps orthopaedic surgeons make better-informed decisions, faster and more accurately. It’s easy to use and identifies the risk of periprosthetic joint infection (PJI) in 15 minutes.

Improving quality of life

Lyfstone® enables the early identification of periprosthetic joint infection, which can prevent later complications or further surgeries.

TIME SAVING

The surgeon can extract the synovial fluid and perform the test immediately while the patient is still present.

COST SAVING

Faster PJI diagnosis results in less bed-days for the patient.

frequently asked questions

Do you have any more questions regarding Lyfstone®?

product materials

Learn more about Lyfstone® from our blog and professional product materials

Evaluation of an upgraded synovial calprotectin
lateral flow assay in unclear cases of hip and knee prosthetic joint infections. Hartmann, Hofstaetter et all 2023

Vienna, 169 patients

Aim: Synovial calprotectin point-of-care test (POC) has shown promising clinical value in diagnosing periprosthetic joint infections…

Calprotectin Lateral
Flow Test:

Consistent Across Criteria for Ruling Out Periprosthetic Joint Infection.

Cleveland Clinic US, 123 patients

BackgroundThere are multiple sets of criteria used to define periprosthetic joint infection. The objective of this study is to…

The synovial fluid calprotectin
lateral flow test for the diagnosis of chronic prosthetic joint infection in failed primary and revision total hip and knee arthroplasty. Suren, Prodinger, et al. 2023

Munich Germany, 137 patients

Purpose The diagnostic criteria of prosthetic joint infection (PJI) recommended by the most commonly used…

Get in touch with

our distributors Or contact Lyfstone directly on info@lyfstone.com

in europe

Our professional distributors
are available throughout Europe. Choose the one closest to you and contact your sales representative today.

Get in touch with

our distributors Or contact Lyfstone directly on info@lyfstone.com

in europe

Our professional distributors
are available throughout Europe. Choose the one closest to you and contact your sales representative today.

Find our latest published studies here!